Introduction

Salicin is contained in willow (the molecular structure diagram of salicin is shown in the figure, especially the salicin content in willow bark is the highest.Salicin has antipyretic, analgesic and other efficacy ‚ for the treatment of diseases such as antipyretic and arthritis.At present ‚ the main ingredient of widely used antipyretics is salicylic acid ‚ but clinical evidence shows that its side effects are relatively large ‚ should be used with caution especially in children.Salicin in the human body can slow change and release salicylic acid ‚ side effects small ‚ is a traditional Chinese herbal medicine.At present, there are many methods for the determination of salicin, such as thin layer chromatography, electrophoresis, electrochemical method and ultraviolet spectroscopy ‚ but these methods are complicated to operate.

Production

(1) Material preparation: crush willow branches and leaves into small pieces of raw material;

(2) Hydrolytic extraction: adding alkaline substances to the raw material for hydrolysis, and then extracting with extractant to remove the residue;

(3) Concentration: obtain the semi-finished product containing salicin extract.

his process has the following advantages: 

1. Easy access to raw materials; 

2.Simple process;

3. High yield: 

The product yield is high, and the purity of salicin obtained through the refining step is ≥95% after production verification

Application

1. Treat fevers, colds and infections

As a "natural aspirin," salicin is used to treat mild fevers, colds, infections (influenza), acute and chronic rheumatic discomfort, headaches and pain due to inflammation.Aspirin (acetylsalicylic acid), as a synthetic substitute for salicin, has potentially dangerous gastrointestinal side effects.As its natural form, salicylic acid is innocently converted into salicylic acid in the blood and liver through the gastrointestinal system.The conversion process takes several hours, so the results are not immediately felt by the body, but the general effect lasts for several hours.

2. Relieve arthritis pain and lower back pain

Salicin is thought to be the source of the anti-inflammatory and pain relieving abilities of white willow bark.The analgesic effect of white willow bark is usually slower but lasts longer than that of regular aspirin products.One trial found that an herbal compound containing 100ng of salicin improved pain relief in arthritis patients after two months.Another trial found that 1360mg of white willow bark extract (containing 240mg of salicin) daily for two weeks was more effective in treating joint pain and/or arthritis.High doses of white willow bark extract may also help with lower back pain.A four-week trial found that white willow bark extract containing 240mg of salicin was effective in reducing the deterioration of low back pain.

3. Remove skin cutin and improve skin quality

In a study entitled "used in cosmetics and skin preparation for external use only salicin as an stimulus compound" patent, salicylic acid is considered in the control and prevention in the so-called "sting" is a kind of effective ingredients, can use salicin treatment of atopic dermatitis, type I and type IV skin irritation, using salicin can improve the stimulus threshold of sensitive skin."Salicin's aspirin-like properties are also thought to be used to eliminate diaper rash, herpetic inflammation and sunburn in concentrations of about 5%.